Publications

A red cell branching out against a black background

Purple, grey, and green clusters of cells against a black background

Yellow and teal cells against a black background

Manuscripts in Referred Journals

Rameshkumar N, Shrestha AP, Boff JM, Hoon M, Matveev V, Zenisek D, Vaithianathan T. Nanophysiology approach reveals diversity in calcium microdomains across zebrafish retinal bipolar ribbon synapses. Elife. 2025 Dec 1;14:RP105875. https://pubmed.ncbi.nlm.nih.gov/41324993/
Wallin J, Miller A, Sinha R, Hoon M. Afferent input differentially regulates establishment and maintenance of synapses in the mammalian retina. Sci Rep. 2025 Nov 20;15(1):41045. https://pubmed.ncbi.nlm.nih.gov/41266494/
Khoussine J, Sawant A, Gupta S, Zhai H, Shahi PK, Pattnaik BR, Sinha R, Hoon M. Divergent mechanisms of neural adaptation and instability in the mammalian retina. Current Biology 2025. Jun 24:S0960-9822(25)00744-4.https://pubmed.ncbi.nlm.nih.gov/40580962/
Grimes WN, Berson DM, Sabnis A, Hoon M, Sinha R, Tian H, Diamond JS. Layer-specific anatomical and physiological features of the retina’s neurovascular unit. Current Biology 2025. Jan 6;35(1):109-120.e4. https://pubmed.ncbi.nlm.nih.gov/39689705/
Maddox JW, Ordemann GJ, de la Rosa Vázquez JAM, Huang A, Gault C, Wisner SR, Randall K, Futagi D, Salem NA, Mayfield D, Zemelman BV, DeVries S, Hoon M, Lee A. A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse. Elife. 2024.Nov 12:13:RP94908. https://pubmed.ncbi.nlm.nih.gov/39531384/
Wisner S, Saha A, Grimes W, Mizerska K, Kolarik H, Wallin J, Diamond J, Sinha R, Hoon M. Sensory deprivation arrests cellular and synaptic development of the night vision circuitry in the retina. Curr Biol 2023 Oct 23;33(20):4415-4429.e3. https://pubmed.ncbi.nlm.nih.gov/37769662/
Saha A, Mian K, Zuniga J, Zhai H, Derr PJ, Hoon M* and Sinha R*. Regional variation in the organization and connectivity of the first synapse in the primate night vision pathway. iScience 2023 Oct 2;26(11):108113. https://pubmed.ncbi.nlm.nih.gov/37915604/.* Co-corresponding authors.
Grimes WN, Sedlacek M, Musgrove M, Nath A, Tian H, Hoon M, Rieke F, Singer JH, Diamond JS. Dendro-somatic synaptic inputs to ganglion cells contradict receptive field and connectivity conventions in the mammalian retina. Curr Biol. 2022 Jan 24;32(2):315-328.e4. https://pubmed.ncbi.nlm.nih.gov/34822767/
Sinha R, Grimes WN, Wallin J, Ebbinghaus BN, Luu K, Cherry T, Rieke F, Rudolph U, Wong RO, Hoon M. Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function. Curr Biol. 2021 Aug 19;S0960-9822(21)01049-6. doi: 10.1016/j.cub.2021.07.059. https://pubmed.ncbi.nlm.nih.gov/34433078/
Nagy J, Ebbinghaus B, Hoon M, Sinha R. GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons. Elife. 2021 Apr 27;10:e60994. doi: 10.7554/eLife.60994. https://pubmed.ncbi.nlm.nih.gov/33904401/
Grimes WN*, Aytürk DZ*, Hoon M*, Yoshimatsu T, Gamlin C, Carrera D, Nath A, Nadal-Nicolás FM, Ahlquist RM, Sabnis A, Berson DM, Diamond JS, Wong RO, Cepko C, Rieke F. A high-density narrow-field inhibitory retinal interneuron with direct coupling to Müller glia. J Neurosci. 2021 Jun 1;41(28):6018-6037. doi: 10.1523/JNEUROSCI.0199-20.2021. https://pubmed.ncbi.nlm.nih.gov/34083252/. * These authors contributed equally.
Sawant A, Ebbinghaus BN, Bleckert A, Gamlin C, Yu W, Berson D, Rudolph U, Sinha R, Hoon M. Organization and emergence of a mixed GABA-glycine retinal circuit that provides inhibition to mouse ON-sustained alpha retinal ganglion cells. Cell Rep. 2021 Mar 16;34(11):108858. doi: 10.1016/j.celrep.2021.108858. https://pubmed.ncbi.nlm.nih.gov/33730586/
Maddox JW, Randall KL, Yadav RP, Williams B, Hagen J, Derr PJ, Kerov V, DellaSantina L, Baker SA, Artemyev N, Hoon M, Lee A. A dual role for Cav1.4 Ca2+channels in the molecular and structural organization of the rod photoreceptor synapse. elife 2020. Sep 17; 9:e62184. doi: 10.7554/eLife.62184. https://pubmed.ncbi.nlm.nih.gov/32940604/
Chan K, Hoon M, Pattnaik BR, Ver Hoeve JN, Wahlgren B, Gloe S, Williams J, Wetherbee B, Kiland JA, Vogel KR, Jansen E, Salomons G, Walters D, Roullet JB, Gibson KM, McLellan GJ. Invest Ophthalmol Vis Sci 2020 Feb 7;61(2):17. Vigabatrin-induced retinal functional alterations and second-order neuron plasticity in C57BL/6J mice.
Sinha R, Siddiqui TJ, Padmanabhan N, Wallin J, Zhang C, Karimi B, Rieke F, Craig AM, Wong RO, Hoon M. Neuron. 2020 Mar 18;105(6):1007-1017.e5. LRRTM4: A novel regulator of presynaptic inhibition and ribbon synapse arrangements of retinal bipolar cells.
Hoon M*, Krishnamoorthy V, Gollisch T, Falkenburger B, Varoqueaux F*. PLoS One 2017 Jul 14;12(7):e0181011. Loss of Neuroligin3 specifically downregulates retinal GABAAa2 receptors without abolishing direction selectivity. * Co-corresponding authors.
Gore BB, Miller SM, Jo YS, Baird MA, Hoon M, Sanford CA, Hunker A, Lu W, Wong RO, Zweifel LS. Elife 2017 Apr 10;6. pii: e23858. Roundabout receptor 2 maintains inhibitory control of the adult midbrain.
Sinha R*, Hoon M*, Baudin J, Okawa H, Wong RO, Rieke F*. Cell 2017 Jan 26;168(3):413-426.e12. Cellular and circuit mechanisms shaping the perceptual properties of the primate fovea. * Co-corresponding authors
Della Santina L, Kuo SP, Yoshimatsu T, Okawa H, Suzuki SC, Hoon M, Tsuboyama K, Rieke F, Wong RO. Curr Biol 2016 Aug 8; 26(15):2070-7.Epub 2016 Jul14. Glutamatergic monopolar interneurons provide a novel pathway of excitation in the mouse retina.
Moore-Dotson JM, Beckman JJ, Mazade RE, Hoon M, Adam S. Bernstein AS, Romero-Aleshire MJ, Brooks HL, Eggers ED. IOVS 2016 Mar 1;57(3):1418-30. Early retinal neuronal dysfunction in diabetic mice: Reduced light-evoked inhibition increases rod pathway signaling.
Hoon M*, Sinha R, Okawa H, Suzuki SC, Hirano AA, Brecha N, Rieke F, Wong RO*. Proc Natl Acad Sci U S A 2015 Oct 13; 112(41): 12840-5. Epub 2015 Sep 29. Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells.* Co-corresponding authors.
Newkirk GS, Hoon M, Wong RO, Detwiler PB. PloS One 2015 Sep 9; 10(9): e0137702. Response properties of a newly identified tristratified narrow field amacrine cell in the mouse retina.
Grimes WN, Zhang J, Tian H, Graydon C, Hoon M, Rieke F, Diamond JS. J Journal Neurophysiol 2015 Jul; 114(1):341-53 . Epub 2015 May 13. Complex inhibitory microcircuitry regulates retinal signaling near visual threshold.
Grimes WN, Hoon M, Briggman KL, Wong RO, Rieke F. Elife 2014 Sep 1:e03892. Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
Newkirk GS, Hoon M, Wong RO, Detwiler PB. J Neurophysiol 2013 Jul;110(2):538-52. Epub 2013 May1. Inhibitory inputs tune the light response properties of dopaminergic amacrine cells in mouse retina.
Schubert T *, Hoon M *, Euler T, Lukasiewicz P, Wong RO. Neuron 2013 Apr 10;78(1):124-37. Developmental regulation and activity-dependent maintenance of GABAergic presynaptic inhibition onto rod bipolar cell axonal terminals. * These authors contributed equally to this work.
Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt K.F, Sassoe-Pognetto M, Loewel S, Moser T, Taschenberger H, Brose N, Varoqueaux F. Proc Natl Acad Sci U S A 2011 Feb 15; 108(7): 3053-8. Epub 2011 Jan 31. Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Jedlicka P, Hoon M, Papadopoulos T, Vlachos A, Winkels R, Poulopoulos A, Betz H, Deller T, Brose N, Varoqueaux F, Schwarzacher S. W. Cereb Cortex 2011 Feb; 21(2): 357-6. Epub 2010 Jun 7. Increased dentate gyrus excitability in Neuroligin 2-deficient mice in vivo.
Poulopoulos A, Aramuni G, Meyer G, Soykan T, Hoon M, Papadopoulos T, Zhang M, Paarmann I, Fuchs C, Harvey K, Jedlicka P, Schwarzacher SW, Betz H, Harvey RJ, Brose N, Zhang W, Varoqueaux F. Neuron 2009 Sep 10; 63(5): 628-42. Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin.
Hoon M, Bauer G, Fritschy JM, Moser T, Falkenburger BH, Varoqueaux F. J Neurosci 2009 Jun 24; 29(25): 8039-50. Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina.

Book Chapters

Della Santina L*, Hoon M*. Image Analysis Routines for Quantification of Synaptic Density and Connectivity. Methods Mol Biol. 2025:2910:179-204. *Co-corresponding authors. https://pubmed.ncbi.nlm.nih.gov/40220100/
Czymmek K, Sawant A, Goodman K, Pennington J, Pedersen P, Hoon M, Otegui M. Imaging Plant Cells by High-pressure Freezing and Serial Block-Face Scanning Electron Microscopy. Methods Mol Biol (2020). 2177:69-81. https://pubmed.ncbi.nlm.nih.gov/32632806/
Hoon M*, Sinha R, Okawa H*. Methods Mol Biol 2017 1538:293-320, Humana Press ISBN 978-1-4939-6688-2. Using fluorescent markers to estimate synaptic connectivity in situ. * Co-corresponding authors

Reviews in Referred Journals

Stevens-Sostre WA and Hoon M. Annu Rev Vis Sci. 2024 Sep;10(1):377-402. Cellular and Molecular Mechanisms Regulating Retinal Synapse Development.
Sawant A, Saha A, Khoussine J, Sinha R and Hoon M. Front. Ophthalmol., 20 April 2023. Sec. Retina. Volume 3 – 2023. New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned.
Gamlin C.R., Yu W., Wong R.O.L., Hoon M. Neural Dev 2018 Jun 7;13(1):12s. Assembly and maintenance of GABAergic and Glycinergic circuits in the mammalian nervous system.
Okawa H*, Hoon M*, Yoshimatsu T, Della Santina L, Wong RO. Neuron 2014 Sep 17;83(6):1303-1318. Illuminating the multifaceted roles of neurotransmission in shaping neuronal circuitry. * These authors contributed equally to this work.
Hoon M, Okawa H, Della Santina L, Wong RO. Prog Retin Eye Res 2014 Sep;42:44-84. Functional architecture of the retina: development and disease.

Commentary

Hoon M. Neural circuit assembly: A sticky cue that connects neurons with a preference for hue. Current Biology 2025. Apr 7;35(7):R255-R258. https://pubmed.ncbi.nlm.nih.gov/40199249/

All Publications